Cell cultures used in biologic manufacturing have stringent requirements that must be met in order to ensure high cell viability and consistent biologic drug yield. With over 50 years’ experience in EO/PO chemistry, BASF is committed to providing the poloxamer Kolliphor,/content/basf/pharmaceutical/global/en/apis-raw-materials,/content/basf/pharmaceutical/global/en/apis-raw-materials/products,/content/basf/pharmaceutical/global/en/apis-raw-materials/products/kolliphor-p-188-bio,Extensive Technology Platform - BASF Intermediates. For protection from shear stress, poloxamer 188 has a long publication history as well as documented use in the manufacturing of approved biologics. Target is an increase in solubility & bioavailability. Product Name: Kolliphor P188 Synonyms/Generic Names: Oxirane, 2-methyl-, polymer with oxirane Product Number: 2898 Product Use: Industrial, Manufacturing or Laboratory use Manufacturer: Columbus Chemical Industries, Inc. N4335 Temkin Rd. Packaging Learn more about Kolliphor® P 188 (Lutrol® F68, Pluronic® F-68, Synperonic® F68). Wetting and dissolution enhancement is also supported in oral, liquid, and oral semi-solid formulations. dispersion, solution, suspension or emulsion. In formulations that include poorly soluble actives, Kolliphor® P 188 … For instant and modified release applications, Kolliphor® P 188 can act as a stabilizer in oral suspensions. Kolliphor ® P407 A polymeric multi-talent suitable for a large variety of applications, i.e. You may need to download version 2.0 now from the,Please complete the security check to access. Visit our Download Center.Cell cultures used in biologic manufacturing have stringent requirements that must be met in order to ensure high cell viability and consistent biologic drug yield. Visit our Download Center./content/basf/pharmaceutical/global/en/drug-formulation,/content/basf/pharmaceutical/global/en/drug-formulation/products,/content/basf/pharmaceutical/global/en/drug-formulation/products/kolliphor-p188. Kolliphor P 188 has been widely used as a thickening agent and gel binder. Many different compounds have been screened for use in protecting the cells from this shear stress, including animal serum, cellulosic derivatives, dextran sulfate, polyethelyne glycols (PEGs), polyvinyl alcohol (PVA) and poloxamers. Through science and innovation we provide our customers with products to meet the current and future needs of business and society. A meltable binder is used to agglomerate drug and other ingredients to reduce recrystallization potential through separation. It is used for lubrication needs in direct compression and dry granulation production of tablets and capsules. as thickening agent and gel former and as a co-emulsifier and viscosity enhancer in creams and liquid emulsions. Kolliphor® P 188 is an poloxamer that enables and enhances a wide range of functional applications. Flexible excipient to overcome a wide range of pharmaceutical challenges that provide formulators with increased efficiency and added functionality.High purity poloxamer designed to reduce shear stress during biologics manufacturing,Focusing on your needs with platform solutions,Trends and Formulation Strategies for Topical Drugs.Melt granulation is a great process option in a formulators' biovailability enhancement arsenal. Revised on 07/27/2020 Page 1 of 5 Safety Data Sheet . Key for a successful process is the use of the right functional polymer to ensure a stable solid dispersion. Kolliphor ® P 188 2 Products Synonym: Lutrol ® F68, Poloxamer 188, Poly(ethylene glycol)- block -poly(propylene glycol)- block -poly(ethylene glycol)
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